Triggers of benign recurrent intrahepatic cholestasis and its pathophysiology: a review of literature

Benign recurrent intrahepatic cholestasis (BRIC) is a rare genetic disorder that characterized by episodes of followed complete resolution. The episodic nature BRIC raises concerns about its possible trigger factors. Indeed, case reports this orphan disease have associated to some triggers. In the absence any reviews, we reviewed factors and pathophysiology. study consisted systematic search for using PubMed. Articles describing clear with were included resulting in 22 articles describe 35 patients. Infection was responsible 54.3% triggered episodes, hormonal, drugs, miscellaneous causes reporting as 30%, 10%, 5.7% respectively. Females predominated 62.9%. longest episode ranged between 3 months 2 years mean 32.37 weeks. age first 14.28 ranging 48 years. Winter autumn major seasons during which happened. Hence, potentially infection, most commonly viral hormonal disturbances seen oral contraceptive pills pregnancy state, less certain drugs other causes. appearance two trimesters compared could help differentiate conditions. mechanism induction implicates role BSEP ATP8B1. While estrogen, cytokines are known affect BSEP, their action on